Adolescent Δ9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-κB-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood
Jouroukhin Y, Zhu X, Shevelkin AV, et al. Biol Psychiatry. 2018 Aug 16. pii: S0006-3223(18)31746-3. doi: 10.1016/j.biopsych.2018.07.024. [Epub ahead of print]
Why do only some people develop cognitive impairment with cannabis use? This biologically-oriented article for the interested shows that genetic predisposition within brain cells known as astrocytes may mediate the cognitive impairments via convergent inflammatory signalling.