How else might the effects of adverse childhood experiences be transmitted to future generations? Results from the Avon Longitudinal Study show that mothers’ ACE exposure is associated with DNAm in male (but not female) offspring, supporting the notion that in some situations, DNAm could be a marker of intergenerational biological embedding of mothers’ childhood adversity.

Pamela Scorza, ScD, MPH , Cristiane S. Duarte, PhD, Seonjoo Lee, PhD, Jonathan Posner, MD, Andrea Baccarelli, PhD, Catherine Monk, PhD. Open AccessPublished:June 14, 2023DOI:https://doi.org/10.1016/j.jaac.2023.02.018

https://www.jaacap.org/article/S0890-8567(23)00313-1/fulltext?dgcid=raven_jbs_etoc_email