Hui CLM, Honer W, Lee E, et al. The Lancet Psychiatry , Published online April 2018.

This paper describes a ten-year follow-up study of a randomised controlled trial from seven centres in Hong Kong in which 178 patients with first-episode psychosis with full positive symptom resolution after at least 1 year of antipsychotic treatment were given maintenance treatment (n=89; oral quetiapine 400 mg daily) or early treatment discontinuation (n=89; placebo) for 12 months. After the trial, patients received naturalistic treatment.  Thirty five (39%) of patients in the discontinuation group and 19 (21%) of patients in the maintenance treatment groups had poor outcomes (risk ratio 1·84, 95% CI 1·15–2·96; p=0·012) indicating that medication continuation for at least the first 3 years after starting treatment decreased the risk of relapse and poor long-term clinical outcomes.  Suicide was the only serious adverse event that occurred in the follow-up phase (four [4%] patients in the early discontinuation group vs two [2%] in the maintenance group.

http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(18)30090-7/fulltext