Birnie KA, Noel M, Chambers CT, et al. Cochrane Database Syst Rev. 2018 Oct 4;10:CD005179. doi: 10.1002/14651858.CD005179.pub4. (Review) PMID: 30284240

This updated Cochrane review of 59 trials found evidence for (i) distraction, (ii) hypnosis and (iii) combined CBT plus breathing interventions for reducing children’s needle-related pain or distress, or both. Despite the quality of evidence being low to very low overall, these interventions are likely to be useful in clinical practice.

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